Integration of genome data and protein structures: prediction of protein folds, protein interactions and 'molecular phenotypes' of single nucleotide polymorphisms

With the massive amount of sequence and structural data being produced, new avenues emerge for exploiting the information therein for applications in several fields. Fold distributions can be mapped onto entire genomes to lea rn about the nature of the protein universe and many of the interactions be tween proteins can now be predicted solely on the basis of the genomic cont ext of their genes. Furthermore, by utilising the new incoming data on sing le nucleotide polymorphisms by mapping them onto three-dimensional structur es of proteins, problems concerning population, medical and evolutionary ge netics can be addressed.