The concept of moist wound healing, which is facilitated by the application
of occlusive dressings, dates back to 1615 BC, and the technique is curren
tly supported by a relatively large volume of data. It is clear that occlus
ive dressings are in many cases associated with more rapid reepithelializat
ion, a reduced risk of infection, and more rapid wound healing than the alt
ernatives. Nevertheless, many clinicians have been slow to accept this ther
apeutic technique. This article traces the history of moist wound healing f
rom its earliest inception, examines the theoretical mechanisms of its effe
ct, and explores its advantages and disadvantages. It also reviews the lite
rature supporting the use of occlusive dressings in a variety of wound sett
ings and examines the possible reasons behind the apparent reluctance on th
e part of the medical community to accept a potentially valuable therapy.