Low serum cholesterol concentration and risk of suicide

Recent reports have suggested a link between low serum total cholesterol an d risk of death from suicide. We examined this association using participan ts in the 1970-1972 Nutrition Canada Survey. We determined the mortality ex perience of Nutrition Canada Survey participants older than 11 years of age at baseline through 1993 by way of record linkage to the Canadian National Mortality Database. The relation between low serum total cholesterol and m ortality from suicide was assessed using a stratified analysis (N = 11,554) . There were 27 deaths due to suicide. Adjusting for age and sex, we found that those in the lowest quartile of serum total cholesterol concentration (<4.27 mmol/liter) had more than six times the risk of committing suicide ( rate ratio = 6.39; 95%, confidence interval = 1.27-32.1) as did subjects in the highest quartile (>5.77 mmol/liter). Increased rate ratios of 2.95 and 1.94 were observed for the second and third quartiles, respectively. The e ffect persisted after the exclusion from the analysis of the first 5 years of follow-up and after the removal of those who were unemployed or who had been treated for depression. These data indicate that low serum total chole sterol level is associated with an increased risk of suicide.