Tremendous advances in our understanding of the human immunodeficiency
viruses (HIVs) have been made through the use of animal models. Howev
er, there are limitations inherent in many of the current models that
use either nonhuman primates, or viruses other than HIV-1. Researchers
continue to search for improved models using small-animal model alter
natives and different viruses, Animal models will remain an important
tool in our continued search for vaccines and therapeutic agents.