Synthesis of new 4-allyl-4-N-benzylaminopiperidines and their spirocyclic products

Authors
Kouznetsov, V Palma, A Salas, S Stashenko, E Montenegro, G Fontela, A
Citation
V. Kouznetsov et al., Synthesis of new 4-allyl-4-N-benzylaminopiperidines and their spirocyclic products, HETEROCYC C, 6(6), 2000, pp. 519-523
Citations number
9
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLIC COMMUNICATIONS
ISSN journal
07930283 → ACNP
Volume
6
Issue
6
Year of publication
2000
Pages
519 - 523
Database
ISI
SICI code
0793-0283(2000)6:6<519:SON4AT>2.0.ZU;2-#
Abstract
A new series of N-substituted 4-allyl-4-N-benzylaminopiperidines and spiro[ 3H-2-benzazepine-3,4,-piperidines] have been prepared as potential psychoti c agents from readily available 4-iminopiperidines, by a sequence of reacti ons that included nucleophilic addition of Grignard reagents and acid-media ted intramolecular cyclisation. Some of the compounds prepared have been te sted in albine mice for the spontaneous motor activity.