Synthesis and evaluation of the trypanocydal activity of 4-alkylamino-6-nitroquinolines

Authors
Tapia, RA Prieto, Y Zamora, G Morello, A Repetto, Y
Citation
Ra. Tapia et al., Synthesis and evaluation of the trypanocydal activity of 4-alkylamino-6-nitroquinolines, HETEROCYC C, 6(6), 2000, pp. 539-544
Citations number
20
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLIC COMMUNICATIONS
ISSN journal
07930283 → ACNP
Volume
6
Issue
6
Year of publication
2000
Pages
539 - 544
Database
ISI
SICI code
0793-0283(2000)6:6<539:SAEOTT>2.0.ZU;2-2
Abstract
A straightforward synthesis of a group of 4-alkylamino-6-nitroquinolines st arting from a common intermediate, 5,8-dimethoxy-6-nitro-4(1H)quinolone (3) under bar, is described. These compounds were tested in vitro as potential anti-trypanosomal agents. Some derivatives were found to have a significan t activity, but less efficient than the control drug.