Synthesis of 3-amino-2-ethoxycarbonyl pyrido[1,2-a]thieno-[2,3-d]-4-pyrimidone derivatives and their antimalarial and cytotoxic activities in vitro.

Authors
Charris, J Dominguez, J Cordero, M Orfila, L Riggione, F Lopez, S Enriz, D Suviere, F
Citation
J. Charris et al., Synthesis of 3-amino-2-ethoxycarbonyl pyrido[1,2-a]thieno-[2,3-d]-4-pyrimidone derivatives and their antimalarial and cytotoxic activities in vitro., HETEROCYC C, 6(6), 2000, pp. 571-578
Citations number
20
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLIC COMMUNICATIONS
ISSN journal
07930283 → ACNP
Volume
6
Issue
6
Year of publication
2000
Pages
571 - 578
Database
ISI
SICI code
0793-0283(2000)6:6<571:SO3P>2.0.ZU;2-6
Abstract
dA series of 3-amino-2-ethoxycarbonyl pyrido[1,2-a]thieno[2,3-d]-4-pyrimido ne 10-13 were prepared in order to investigate their cytotoxicity and antim alarial activities. Some of the them showed a promising activity. The detai led synthesis, spectroscopic, computational and biological data are describ ed.