Lymphoepithelioma-like carcinoma of the breast: lack of evidence of Epstein-Barr virus infection

Aims: Six cases of lymphoepithelioma-like carcinomas of the breast were stu died in order to better define the morphology of this type of breast tumour and to see if these neoplastic lesions are related to Epstein-Barr virus ( EBV) infection by analogy with histologically similar tumours located in ot her organs. Methods and results: The cases were studied with immunohistochemistry using several antibodies and with irm-situ hybridization method employing differ ent types of nucleotides in four cases. The cases presented the distinctive morphology of the lymphoepithelioma-like carcinomas as seen in other organ s. Specifically Rigaud and Schminke's patterns of growth were observed. In addition, at the edge of the neoplastic lesions, a lymphoepithelial lobulit is was seen. In-situ hybridization failed to reveal any positivity for EBV genome. Conclusion: Lymphoepithelioma-like carcinoma is a specific type of breast t umour, but its relation to EBV has yet to be proven. The differential diagn osis with medullary carcinoma is discussed.