A convenient synthesis of d-Sotalol

Authors
Phukan, P Jagtap, HS Sudalai, A
Citation
P. Phukan et al., A convenient synthesis of d-Sotalol, I J CHEM B, 39(12), 2000, pp. 950-953
Citations number
11
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
ISSN journal
03764699 → ACNP
Volume
39
Issue
12
Year of publication
2000
Pages
950 - 953
Database
ISI
SICI code
0376-4699(200012)39:12<950:ACSOD>2.0.ZU;2-E
Abstract
Synthesis of d-Nifenalol and d-Sotalol has been achieved in high enantiomer ic purity via Sharpless asymmetric dihydroxylation of 4-nitrostyrene follow ed by the regiospecific opening of chiral cyclic sulfate with isopropylamin e.