K. Kashiwabara et H. Nakamura, Analgesic-induced asthma caused by 2.0% ketoprofen adhesive agents, but not by 0.3% agents, INTERN MED, 40(2), 2001, pp. 124-126
A 74-year-old woman was admitted with an asthma attack. She had a 40-year h
istory of sinusitis, nasal polyp and analgesic-induced asthma; however, ast
hma had never occurred when she used a 0.3% ketoprofen adhesive patch (Mohr
us(R)) for stiff shoulder or lumbago, In the hospital, a life-threatening a
sthma attack suddenly occurred two and a half hours after application of a
2.0% ketoprofen adhesive tape (Mohrus tape(R)) to her shoulder. She was tre
ated with bronchodilator and glucocorticoid and extubated after 20 hours. A
drug lymphocyte stimulating test (DLST) was strongly positive for ketoprof
en, We suspected that drug-induced hypersensitivity coexisted in the presen
t case, but it was not clear whether or not the hypersensitivity was relate
d to the pathogenesis of analgesic-induced asthma.