Studies on the biosynthesis of epothilones: The PKS and epothilone C/D monooxygenase

Authors
Gerth, K Steinmetz, H Hofle, G Reichenbach, H
Citation
K. Gerth et al., Studies on the biosynthesis of epothilones: The PKS and epothilone C/D monooxygenase, J ANTIBIOT, 54(2), 2001, pp. 144-148
Citations number
8
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF ANTIBIOTICS
ISSN journal
00218820 → ACNP
Volume
54
Issue
2
Year of publication
2001
Pages
144 - 148
Database
ISI
SICI code
0021-8820(200102)54:2<144:SOTBOE>2.0.ZU;2-4
Abstract
Nonproducer mutants support the assumption that epothilones A and B are syn thesized by the same polyketide synthase (PKS). The endproducts of the PKS, epothilones C and D, compete for the active site of a constitutively synth esized monooxygenase which is regulated by product inhibition. The postulat ed C-13 hydroxy-epothilones as direct precursors of epothilones C and D wer e not detected.