Efficacy of moxifloxacin, trovafloxacin, clinafloxacin and levofloxacin against intracellular Legionella pneumophila

Citation
D. Jonas et al., Efficacy of moxifloxacin, trovafloxacin, clinafloxacin and levofloxacin against intracellular Legionella pneumophila, J ANTIMICRO, 47(2), 2001, pp. 147-152
Citations number
33
Categorie Soggetti
Pharmacology,Microbiology
Journal title
Journal of antimicrobial chemotherapy
ISSN journal
03057453 → ACNP
Volume
47
Issue
2
Year of publication
2001
Pages
147 - 152
Database
ISI
SICI code
Abstract
This study compares the in vitro activity of novel fluoroquinolones against clinical Legionella pneumophila isolates. We determined both the MICs and intracellular efficacy of moxifloxacin, trovafloxacin, clinafloxacin and le vofloxacin in the Mono Mac 6 infection model. Six legionella strains were t ested and all proved highly susceptible to the fluoroquinolones. Clinafloxa cin and trovafloxacin were found to have the lowest MICs (0.004 mg/L) follo wed by levofloxacin and moxifloxacin (0.015-0.03 mg/L). In the Mono Mac 6 i nfection model, inhibition of L. pneumophila was achieved at concentrations four times below the respective in vitro MICs. Concentrations as low as 0. 015 mg/L of moxifloxacin and levofloxacin, 0.004 mg/L of trovafloxacin and 0.002 mg/L of clinafloxacin markedly decreased viable intracellular bacteri al counts. These data strongly support further clinical evaluation of new f luoroquinolones for empirical treatment of lower respiratory tract infectio n including atypical pneumonia caused by L. pneumophila.