Efficacy of the partricin derivative SPA-S-753 against systemic murine candidosis

The polyene partricin compound SPA-S-753 (Societa Prodotti Antibiotici, Mil ano, Italy) was assessed in a murine model of systemic candidosis. CD-1 mic e were infected iv with Candida albicans and treated iv with SPA-S-753 or a mphotericin B. Ail treatment regimens of SPA-S-753 or amphotericin B were e quivalent and significantly prolonged survival compared with controls (P < 0.001). Amphotericin B and SPA-S-753 significantly reduced burdens of C. al bicans in the spleen and kidneys. Overall, cure rates were similar, amphote ricin B at 1 mg/kg cured three and SPA-S-753 at 10 mg/kg cured four mice of infection in both organs. The efficacy of SPA-S-753 is between equivalent and <10-fold as potent as amphotericin B. These results are encouraging and warrant further studies on SPA-S-753.