Single-dose pharmacokinetics of levofloxacin during continuous veno-venoushaemofiltration in critically ill patients

The present study was performed to analyse the pharmacokinetics of levoflox acin during continuous veno-venous haemofiltration (CVVH) with a high-flux polyamide membrane. Twelve patients received 500 mg levofloxacin intravenou sly. The mean levofloxacin concentration peak was 1.9 +/- 1.0 mg/L. The eli mination half-life, haemofiltration clearance and total removal were 8.3 +/ - 2.6 h, 27.6 +/- 8.4 mg/Lmin and 56 +/- 19%, respectively. Further multipl e-dose studies are required to enable dosage recommendations to be made for patients receiving venal replacement therapy with CVVH.