A. Henriksson et Pl. Conway, Isolation of human faecal bifidobacteria which reduce signs of Salmonella infection when orogastrically dosed to mice, J APPL MICR, 90(2), 2001, pp. 223-228
Aims: The aim of the study was to isolate human bifidobacteria that inhibit
growth of Salmonella typhimurium in vitro, and provide protection against
Salmonella infection in mice.
Methods and Results: A total of 92 micro-organisms, which displayed antagon
ist activity against Saint. typhimurium in vitro, were isolated from human
faecal material. Based on their Gram stain status, cultures were pooled and
tested for anti-Salmonella activity. The Gram-variable group was the most
active. From that group, three bifidobacteria (Lafti(TM)B22, B74 and B97) i
ndividually showed good pathogen inhibition in vivo.
Conclusions: Oral administration of certain human bifidobacteria provides p
rotection against Salmonella infection in mice.
Significance and Impact of the Study: These results indicate that certain b
ifidobacteria may be used as a prophylaxis for reduced incidence and severi
ty of Salmonella infections.