The effect of a continuous positive airway pressure (CPAP) of 12 cm H2
O on mean middle cerebral artery flow velocity (CBFV) was studied in n
ine human volunteers by means of transcranial Doppler sonography (TCD)
. During CPAP breathing, CBFV increased (45 +/- 9 vs 59 +/- 11 cm/s;P
< 0.001; mean +/- SD), and pulsatility index (PI) decreased (0.87 +/-
0.1 vs 0.74 +/- 0.2; P < 0.05), indicating an increase in cerebral blo
od flow due to cerebral vasodilation. This phenomenon should be taken
into account when CPAP is applied to patients with intracranial diseas
e or when assessing CBFV patterns of patients during CPAP respiration.