New single-isomer chiral selector for capillary electrophoresis: the highly water-soluble heptakis(2-N,N-dimethylcarbamoyl)-beta-cyclodextrin

Authors
Christians, T Holzgrabe, U
Citation
T. Christians et U. Holzgrabe, New single-isomer chiral selector for capillary electrophoresis: the highly water-soluble heptakis(2-N,N-dimethylcarbamoyl)-beta-cyclodextrin, J CHROMAT A, 911(2), 2001, pp. 249-257
Citations number
35
Categorie Soggetti
Chemistry & Analysis","Spectroscopy /Instrumentation/Analytical Sciences
Journal title
JOURNAL OF CHROMATOGRAPHY A → ACNP
Volume
911
Issue
2
Year of publication
2001
Pages
249 - 257
Database
ISI
SICI code
Abstract
A new single isomer P-cyclodextrin, the heptakis(2-N,N-dimethylcarbamoyl)-b eta -cyclodextrin (HDMC-beta -CD), has been synthesized and spectroscopical ly characterized. The outstanding feature of the new neutral beta -CD deriv atives is their high solubility in water (>100 mM) and methanol. The resolu tion of chiral drugs can take advantage of this property. The resolution po wer of the new HDMC-beta -CD is demonstrated by a selection of acidic and b asic compounds using standard conditions. (C) 2001 Elsevier Science BN. All rights reserved.