The "serendipitous" surgical cure of the Zollinger-Ellison syndrome in a patient with multiple endocrine neoplasia type 1 despite an unsuspected diagnosis of either disease

Zollinger-Ellison syndrome (ZES) is a relatively uncommon disease that usua lly presents with peptic ulcer disease or refractory diarrhea. It occurs as a component of multiple endocrine neoplasia type 1 (MEN-I) syndrome in mor e than 25% of cases. Surgical management of MEN-1 ZES remains controversial . In this case report, we describe the serendipitous cure of ZES in a patie nt with recurrent peptic ulcer disease who underwent two surgical procedure s. The diagnosis of MEN-I ZES syndrome was neither suspected nor recognized during either operation. This case is presented to highlight the important principles in the diagnosis and current management of patients with MEN-1 ZES.