An ideal trial to test differential onset of antidepressant effect

Although various published clinical studies have suggested that some antide pressants may have a more rapid onset of therapeutic effect than others, no ne of these trials was adequately designed to measure differential time to onset of effect. Thus, existing data do not support claims that one drug re duces the symptoms of depression faster than another. in this article, we p ropose a study that would be ideal for measuring comparative onset of antid epressant effect. The key features of this ideal trial include (1) a prospe ctive definition of early onset of action, (2) increased frequency of asses sment, (3) a data-analytic approach capable of capturing the dynamic nature of symptomatic change, and (4) various strategies to minimize bias and het erogeneity of response.