The localization of persistent foot and mouth disease virus in the epithelial cells of the soft palate and pharynx

Authors
Zhang, ZD Kitching, RP
Citation
Zd. Zhang et Rp. Kitching, The localization of persistent foot and mouth disease virus in the epithelial cells of the soft palate and pharynx, J COMP PATH, 124(2-3), 2001, pp. 89-94
Citations number
16
Categorie Soggetti
Veterinary Medicine/Animal Health","Medical Research Diagnosis & Treatment
Journal title
JOURNAL OF COMPARATIVE PATHOLOGY
ISSN journal
00219975 → ACNP
Volume
124
Issue
2-3
Year of publication
2001
Pages
89 - 94
Database
ISI
SICI code
0021-9975(200102/04)124:2-3<89:TLOPFA>2.0.ZU;2-B
Abstract
After contact with foot and mouth disease virus (FMDV), cattle may become p ersistently infected, regardless of their pre-existing immune status or whe ther they develop clinical disease. The cellular sites of FMDV persistence have not previous been determined. The use of in-situ hybridization in comb ination with tyramide signal amplification (TSA) provided the first direct evidence that FMDV RNA is localized within the epithelial cells of the soft palate and pharynx during persistent infection. indicating that these cell s remain persistently infected after contact with FMDV. (C) 2001 Harcourt P ublishers Ltd.