Toxicity studies of Rhizoma Polygonati Odorati

The toxicity of the water-soluble extract of Rhizoma Polygonati Odorati was studied in the present investigation, which included its acute toxicity, c hronic toxicity, and genetic toxicity. The aqueous extract of Rhizoma Polyg onati Odorati did not cause seriously abnormal signs or death to animals in the acute toxicity test and in the 6-month chronic toxicity test. Neither was genetic toxicity found in the Ames test, the micronucleus test of bone marrow and the sperm malformation test in mice. (C) 2001 Elsevier Science I reland Ltd. All rights reserved.