Neoadiuvant treatment with intravesical interleukin-2 for recurrent superficial transitional bladder carcinoma Ta-T1/G1-2

The aim of this study was to evaluate the direct action of IL-2 on recurren t superficial transitional bladder carcinoma and the effect on recurrence r ate. 27 patients were submitted to neoadjuvant treatment by intra-vesical i nstillation of recombinant IL-2 and to transurethral resection. We did not observe any effect on neoplasms but the recurrence rate was less than the e xpected one. It is possible that treatment of bladder carcinoma with intra- vesical instillation of IL-2 may promote immuno-prophilaxis.