Diagnostic feature extraction with consideration of interactions between va
riables is very important, but has been neglected in most diagnostic resear
ch. In this paper, a new feature extraction methodology is developed to con
sider variable interactions by using a fractional factorial design of exper
iments (DOE). In this methodology, features are extra ted by using principa
l component analysis (PCA) to represent variation patterns of tonnage signa
ls. Regression analyses are performed to model the relationship between fea
tures and process variables. Hierarchical classifiers and the cross-validat
ion method are used for root-cause determination and diagnostic performance
evaluation. A real-world example is used to illustrate the new methodology
.