A PHARMACOPHORE MODEL FOR PDE-IV INHIBITORS

Authors
POLYMEROPOULOS EE HOFGEN N
Citation
Ee. Polymeropoulos et N. Hofgen, A PHARMACOPHORE MODEL FOR PDE-IV INHIBITORS, Quantitative structure-activity relationships, 16(3), 1997, pp. 231-234
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Quantitative structure-activity relationships → ACNP
ISSN journal
09318771
Volume
16
Issue
3
Year of publication
1997
Pages
231 - 234
Database
ISI
SICI code
0931-8771(1997)16:3<231:APMFPI>2.0.ZU;2-#
Abstract
Based on conformational analysis and GRID-contour calculations we deve loped a common primary pharmacophore for rolipram analog, nitraquazone and xanthine derivative PDE IV inhibitors. In spite of the structural differences exhibited by the three substance classes we could provide evidence that they share common hydrogen bonding and lipophilic enzym e binding sites.