Rj. Goody et I. Kitchen, Influence of maternal milk on functional activation of delta-opioid receptors in postnatal rats, J PHARM EXP, 296(3), 2001, pp. 744-748
Citations number
24
Categorie Soggetti
Pharmacology & Toxicology
Journal title
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Weaning rat pups at day 21 activates a delta -opioid receptor that mediates
swim-stress-induced analgesia (swim SIA). We have addressed the possibilit
y that removal of maternal milk is the stimulus for the weaning-induced del
ta -receptor activation by studying the effect of lactating and nonlactatin
g surrogate mothers and two milk substitutes (casein-rich and casein-free)
on opioid receptor control of swim SIA. The delta -receptor antagonist nalt
rindole (1 mg/kg) significantly antagonized swim SIA in 25-day-old weaned r
ats, in rats provided with a nonlactating surrogate, and those provided wit
h casein-free milk substitute. Naltrindole had no effect in nonweaned pups,
pups given a casein-rich substitute, or in pups from litters provided with
a lactating surrogate from day 21 to day 25. Weaning-induced activation of
delta -receptors involved in mediating swim SIA appears to be dependent on
the loss of dietary casein, which is known to produce peptide fragments th
at can exert opioid activity. The data suggest that exposure to exogenous o
pioid peptides can influence the ontogenesis of mu- and delta -opioid recep
tors.