Solvation dynamics of DCM in human serum albumin

Authors
Pal, SK Mandal, D Sukul, D Sen, S Bhattacharyya, K
Citation
Sk. Pal et al., Solvation dynamics of DCM in human serum albumin, J PHYS CH B, 105(7), 2001, pp. 1438-1441
Citations number
58
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
JOURNAL OF PHYSICAL CHEMISTRY B
ISSN journal
15206106 → ACNP
Volume
105
Issue
7
Year of publication
2001
Pages
1438 - 1441
Database
ISI
SICI code
1520-6106(20010222)105:7<1438:SDODIH>2.0.ZU;2-0
Abstract
Solvation dynamics of 4-(dicyanomethylene)-2-methyl-6- (p-dimethylaminostyr yl) 4H-pyran (DCM) in aqueous solution of a protein, human serum albumin (H SA), is studied using picosecond time-resolved emission spectroscopy. The s olvation dynamics of DCM bound to HSA is found to be biexponential with one component of 600 +/- 100 ps (25%) and a very long component of 10 +/- 1 ns (75%). This indicates that the motion of the water molecules in the vicini ty of the protein is highly constrained.