Synthesis of trisphaeridine and norchelerythrine through palladium-catalyzed aryl-aryl coupling reaction

Authors
Harayama, T Akamatsu, H Okamura, K Miyagoe, T Akiyama, T Abe, H Takeuchi, Y
Citation
T. Harayama et al., Synthesis of trisphaeridine and norchelerythrine through palladium-catalyzed aryl-aryl coupling reaction, J CHEM S P1, (5), 2001, pp. 523-528
Citations number
40
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
ISSN journal
14727781 → ACNP
Issue
5
Year of publication
2001
Pages
523 - 528
Database
ISI
SICI code
1472-7781(2001):5<523:SOTANT>2.0.ZU;2-Q
Abstract
Total syntheses of trisphaeridine (3) and norchelerythrine (4), fully aroma tized benzo[c]phenanthridine alkaloids, were accomplished via the internal aryl-aryl coupling reaction of halo amides protected by a methoxymethyl gro up with the palladium reagent, followed by reduction with lithium aluminium hydride and treatment with hydrochloric acid.