Expression of human MxA protein in mosquito cells interferes with LaCrossevirus replication

Authors
Miura, TA Carlson, JO Beaty, BJ Bowen, RA Olson, KE
Citation
Ta. Miura et al., Expression of human MxA protein in mosquito cells interferes with LaCrossevirus replication, J VIROLOGY, 75(6), 2001, pp. 3001-3003
Citations number
15
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF VIROLOGY
ISSN journal
0022538X → ACNP
Volume
75
Issue
6
Year of publication
2001
Pages
3001 - 3003
Database
ISI
SICI code
0022-538X(200103)75:6<3001:EOHMPI>2.0.ZU;2-X
Abstract
Human MxA protein inhibits LaCrosse virus (LAC virus; family Bunyaviridae) replication in vertebrate cells and MxA-transgenic mice. LAC virus is trans mitted to humans by Aedes triseriatus mosquitoes. In this report, we have s hown that transfected mosquito cells expressing the human MxA cDNA are resi stant to LAC virus but permissive for Sindbis virus (family Togaviridae) in fection.