Membrane-anchored peptide inhibits human immunodeficiency virus entry

Authors
Hildinger, M Dittmar, MT Schult-Dietrich, P Fehse, B Schnierle, BS Thaler, S Stiegler, G Welker, R von Laer, D
Citation
M. Hildinger et al., Membrane-anchored peptide inhibits human immunodeficiency virus entry, J VIROLOGY, 75(6), 2001, pp. 3038-3042
Citations number
30
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF VIROLOGY
ISSN journal
0022538X → ACNP
Volume
75
Issue
6
Year of publication
2001
Pages
3038 - 3042
Database
ISI
SICI code
0022-538X(200103)75:6<3038:MPIHIV>2.0.ZU;2-P
Abstract
Peptides derived from the heptad repeats of human immunodeficiency virus (H IV) gp41 envelope glycoprotein, such as T20, can efficiently inhibit HIV ty pe 1 (HIV-1) entry. In this study, replication of HTV-1 was inhibited more than 100-fold in a T-helper cell line transduced with a retrovirus vector e xpressing membrane-anchored T20 on the cell surface. Inhibition was indepen dent of coreceptor usage.