Regional sensitivity and coupling of BOLD and CBV changes during stimulation of rat brain

Authors
Mandeville, JB Jenkins, BG Kosofsky, BE Moskowitz, MA Rosen, BR Marota, JJA
Citation
Jb. Mandeville et al., Regional sensitivity and coupling of BOLD and CBV changes during stimulation of rat brain, MAGN RES M, 45(3), 2001, pp. 443-447
Citations number
16
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
Journal title
MAGNETIC RESONANCE IN MEDICINE
ISSN journal
07403194 → ACNP
Volume
45
Issue
3
Year of publication
2001
Pages
443 - 447
Database
ISI
SICI code
0740-3194(200103)45:3<443:RSACOB>2.0.ZU;2-S
Abstract
Functional MRI of rat brain was performed at 2 Tesla following intravenous injection of cocaine in order to 1) determine if changes in CBV and changes in BOLD signal were regionally coupled in brain parenchyma, and 2) compare the sensitivities of these imaging methods across different brain structur es. Percent changes in CBV and BOLD relaxation rate were spatially and temp orally coupled during this graded brain activation. The use of contrast age nt increased functional sensitivity in all parenchymal brain structures, wi th a strong but predictable dependence on the resting-state blood volume fr action. (C) 2001 Wiley-Liss, Inc.