A direct quantitative relationship between the functional properties of human and macaque V5

Citation
G. Rees et al., A direct quantitative relationship between the functional properties of human and macaque V5, NAT NEUROSC, 3(7), 2000, pp. 716-723
Citations number
40
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NATURE NEUROSCIENCE
ISSN journal
10976256 → ACNP
Volume
3
Issue
7
Year of publication
2000
Pages
716 - 723
Database
ISI
SICI code
1097-6256(200007)3:7<716:ADQRBT>2.0.ZU;2-Z
Abstract
The nature of the quantitative relationship between single-neuron recording s in monkeys and functional magnetic resonance imaging (fMRI) measurements in humans is crucial to understanding how experiments in these different sp ecies are related, yet it remains undetermined. We measured brain activity in humans attending to moving visual stimuli, using blood oxygenation level -dependent (BOLD) fMRI. Responses in Vs showed a strong and highly linear d ependence on increasing strength of motion signal (coherence). These popula tion responses in human Vs had a remarkably simple mathematical relationshi p to previously observed single-cell responses in macaque Vs. We provided a n explicit quantitative estimate for the interspecies comparison of single- neuron activity and BOLD population responses. Our data show previously unk nown dissociations between the functional properties of human Vs and other human motion-sensitive areas, thus predicting similar dissociations for the properties of single neurons in homologous areas of macaque cortex.