Dc. Rice, Identification of functional domains affected by developmental exposure tomethylmercury: Faroe Islands and related studies, NEUROTOXICO, 21(6), 2000, pp. 1039-1044
The Faroe Islands study is a prospective study designed to assess the neuro
logical and behavioral consequences of in utero exposure to methylmercury (
meHg). Maternal exposure to meHg was through consumption of fish and interm
ittent higher-level exposure through pilot whale meat, while consumption of
pilot whale blubber resulted in maternal exposure to PCBs. Analysis of the
neurobehavioral domains affected revealed impairment in attention, memory,
and auditory processing, impairment in primary auditory function, and to a
lesser extent motor impairment. For four of the eight endpoints affected b
y meHg exposure at p <. 10, impairment was also correlated (p<.10) with in
utero PCB exposure as measured by cord tissue PCB levels. Further analyses
provide evidence for an independent effect of PCBs and meHg on these endpoi
nts. Cross-sectional studies in a smaller number of children in the Amazon
and Madeira by the same group of investigators, in which average meHg mater
nal hair levels were about twice as high those in the Faroe Islands, identi
fied auditory, visual, and/or motor deficits, with little or. no evidence o
f deficits in attention or memory. However, the results of the cross-sectio
nal studies must be interpreted with caution, due to limited statistical po
wer as well as a lack of opportunity to correlate effects to in utero expos
ure. (C) 2000 Inter Press, Inc.