3-[I-123]iodo-alpha-methyl-L-tyrosine transport and 4F2 antigen expressionin human glioma cells

Authors
Langen, KJ Bonnie, R Muhlensiepen, H Jansen, P Broer, S Holschbach, M Coenen, HH
Citation
Kj. Langen et al., 3-[I-123]iodo-alpha-methyl-L-tyrosine transport and 4F2 antigen expressionin human glioma cells, NUCL MED BI, 28(1), 2001, pp. 5-11
Citations number
38
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
NUCLEAR MEDICINE AND BIOLOGY
ISSN journal
09698051 → ACNP
Volume
28
Issue
1
Year of publication
2001
Pages
5 - 11
Database
ISI
SICI code
0969-8051(200101)28:1<5:3TA4AE>2.0.ZU;2-W
Abstract
3[I-123]iodo-alpha -methyl-L-tyrosine is a tracer of amino acid transport i n brain tumors using single-photon emission-computed tomography and predomi nantly transported by amino acid transport system L. The 4F2 antigen has be en identified to be linked to system L-like transport and is assumed to be a part of the transporter protein. We demonstrated that system L-mediated t ransport of IMT and 4F2 antigen expression are dependent on proliferation r ate of human glioma cells and significantly correlated with each other. (C) 2001 Elsevier Science Inc, All rights reserved.