P. Bernhardt et al., Biokinetics of In-111-DTPA-D-Phe(1)-octreotide in nude mice transplanted with a human carcinoid tumor, NUCL MED BI, 28(1), 2001, pp. 67-73
The long time biokinetics of the radiolabeled somatostatin analogues In-111
-DTPA-D-Phe(1)-octreotide was studied in nude mice transplanted with the hu
man carcinoid tumor, GOT1. The results were compared with those from the pa
tient with the original tumor. This patient has been diagnosed and later tr
eated with In-111-DTPA-D-Phe(1)-octreotide. The animals received about 2 MB
q In-111-DTPA-D-Phe(1)-octreotide (0.1 mug) by injection into a tail vein.
The animals were killed 0.5 h-14 d after injection of the radiopharmaceutic
al. Tumor tissue and normal tissues were collected and weighed and measured
for In-111 activity. The In-111 uptake in the tumor was higher than in all
normal tissues except the kidneys, The tumor-to-normal-tissue activity con
centration, TNC, increased with time for all normal tissues studied. These
data were similar to those observed for the original tumor in the patient.
The similar biokinetics for In-111-DTPA-D-Phe(1)-octreotide in the tumor-be
aring mice and the patient makes this animal model suitable as a model for
evaluation of therapy of somatostatin receptor (sstr) expressing tumors wit
h radiolabeled somatostatin analogues. Furthermore, the increase with time
of TNC both in mice and the patient indicates that long-lived radionuclides
are preferred for therapy with radiolabeled somatostatin analogues. (C) 20
01 Elsevier Science Inc. All rights reserved.