PREPARATION AND CHARACTERIZATION OF MONOCLONAL-ANTIBODIES TO FOOT-AND-MOUTH-DISEASE VIRUS TYPE ASIA-1

Authors
AMINEVA SP DAVYDOVA NL MAMATKULOVA LU GLOBENKO LA MISHCHENKO VA
Citation
Sp. Amineva et al., PREPARATION AND CHARACTERIZATION OF MONOCLONAL-ANTIBODIES TO FOOT-AND-MOUTH-DISEASE VIRUS TYPE ASIA-1, Biochemistry, 62(5), 1997, pp. 469-473
Citations number
18
Categorie Soggetti
Biology
Journal title
Biochemistry → ACNP
ISSN journal
00062979
Volume
62
Issue
5
Year of publication
1997
Pages
469 - 473
Database
ISI
SICI code
0006-2979(1997)62:5<469:PACOMT>2.0.ZU;2-A
Abstract
Eight clones of hybrid cells secreting monoclonal antibodies to foot-a nd-mouth disease virus type Asia-1 were prepared; three of them neutra lized viral infection. The specificity of THE monoclonal antibodies wa s analyzed by various immunoenzyme assays using 146S viral particles, trypsin-treated 146S particles, 12S particles, and certain viral polyp eptides. The epitopes unique for virus type Asia-1 and conservative am ong several types were detected on the surface of viral particles. Epi topes on the surface of viral particle were mapped.