Endoscope-compatible confocal microscope using a gradient index-lens system

We present an endoscope-compatible confocal laser scanning microscope (CLSM ) for medical imaging. A gradient index (GRIN)-lens system projects a magni fied image on the distal end of a fiber-optic imaging bundle, which transfe rs the image to a CLSM situated at the proximal end. As the maximum diamete r of the distal optics is I mm, application through the accessory channel o f a conventional endoscope is possible. A lateral resolution of 3.1 mum and an axial resolution of 16.6 mum is achieved. Confocal images of colonic ti ssue stained with a fluorescent marker are shown. (C) 2001 Published by Els evier Science B.V.