Temporary myoclonus with treatment of congenital transcobalamin 2 deficiency

The treatment of acquired cobalamin deficiency in infants may result in the development of a syndrome defined by temporary involuntary myoclonic movem ents. A patient with an inborn error of metabolism resulting in transcobalm in 2 deficiency who was treated with cobalamin and then developed this synd rome is presented. Neurologic Investigations were normal. The continuance o f cobalamin and avoidance of antiepileptic drugs is recommended, To our kno wledge this is the first such case. (C) 2001 by Elsevier Science Inc. All r ights reserved.