Ma. Pullen et al., Stimulation of hyaluronan synthetase by platelet-derived growth factor bb in human prostate smooth muscle cells, PHARMACOL, 62(2), 2001, pp. 103-106
Hyaluronic acid (HA) is an important component of the extracellular matrix
of prostate cells. Platelet-derived growth factor bb (PDGFbb) has a mitogen
ic effect on prostate stromal cells. The effect of PDGFbb on HA production
by smooth muscle cells from normal and benign prostatic hyperplasia (BPH) t
issue was studied to elucidate the role of these two factors in BPH, The ba
sal level of HA released into the cell media was greater in BPH cells. PDGF
bb increases HA production in normal and BPH smooth muscle cells. This is p
artly due to an increase in HA synthetase II mRNA expression. In prostate d
isease, PDGFbb may have a role that involves HA production. Copyright (C) 2
001 S. Karger AG. Basel.