Pulmonary mucosa-associated lymphoid tissue lymphoma in a patient with common variable immunodeficiency syndrome

Common variable immunodeficiency syndrome (CVID) is a primary immunodeficie ncy typically presenting with recurrent sinopulmonary infections. Non-Hodgk in's lymphoma and other secondary cancers are typical late complications of CVID. We report on a patient suffering from CVID with a history of recurre nt sinopulmonary infections, interstitial pulmonary changes and hepatic gra nulomas. Despite treatment with intravenous immunoglobulin followed by a re duction in the number of pulmonary infections, reticular and nodular lung c hanges progressed. Video-assisted thoracoscopic lung biopsy showed a low-gr ade B cell lymphoma of the mucosa-associated lymphoid tissue (MALT) of the bronchus without evidence of pulmonary infection. In conclusion, MALT lymph oma of the lung should be considered in the differential diagnosis of progr essive lung disease in CVID. Copyright(C)2001 S. Karger AG,Basel.