Competing risks analysis of patients with osteosarcoma: a comparison of four different approaches

In failure time studies involving a chronic disease such as cancer, several competing causes of mortality may be operating. Commonly, the conventional statistical technique of Kaplan-Meier, which is only meaningfully interpre ted by assuming independence of failure types and the censoring mechanism, is employed in clinical research involving competing risks data. Some autho rs have advocated the use of a cause-specific cumulative incidence function which takes into account the existence of other events within a competing risks framework, without making any assumption about independence. Lunn and McNeil have proposed an approach based on an extension of the Cox proporti onal hazards regression, which enables direct comparisons between failure t ypes. We have extended this approach to estimate cause-specific cumulative incidence. As it is often not easy to follow competing risks methodology in the literature, this paper sets out systematically the assumptions made an d the steps taken to implement four different methods of analysing competin g risks data using cumulative incidence rates or the Kaplan-Meier estimates of cause-specific failure probabilities. The data obtained from a randomiz ed trial of patients with osteosarcoma were used to compare these four appr oaches. As illustrated using the osteosarcoma data, the estimates of the cl assical Kaplan-Meier methods have larger numerical values than the cause-sp ecific cumulative incidence. On the other hand, estimates of the cause-spec ific cumulative incidence rates from the conventional method and the modifi ed Cox method are highly comparable. Copyright (C) 2001 John Wiley & Sons, Ltd.