Improved recovery in activities of daily living associated with remission of poststroke depression

Background mid Purpose-Poststroke depression is associated with impaired re covery of activities of daily living (ADL) function compared with similar n ondepressed patients. We examined the differences on recovery of ADL functi ons among poststroke depressed patients with remission of their depression compared with poststroke depressed patients without mood recovery over the first 3 to 6 months after stroke. Methods-On the basis of a semistructured psychiatric examination and DSM-IV diagnostic criteria, a consecutive series of patients with poststroke majo r or minor depression (n=55) were selected. Their impairment in ADL functio n was assessed by means of the Johns Hopkins Functioning Examination during acute hospitalization and either 3 or 6 months later. Results-Patients whose mood improved at follow-up (n=21) had significantly greater recovery in ADL functions at follow-up than patients whose mood did not improve (n=34). There were no differences in demographic variables, le sion characteristics, and neurological symptoms between the two groups. Fur thermore, patients with either major or minor depression at the initial eva luation showed the same amount of recovery in ADL function if they improved at follow-up. Conclusions-Our findings suggest that remission of poststroke depression ov er the first few months after stroke is associated with greater recovery in ADL function than continued depression. Early effective treatment of depre ssion may have a positive effect on the rehabilitation outcome of stroke pa tients.