Surgical management of peptic ulcer disease in the helicobacter era-management of bleeding peptic ulcer

Bleeding continues to be a significant cause of morbidity and mortality for patients with peptic ulcer disease. Recent advances have changed the manag ement of this disease. Upper endoscopy with or without endoscopic therapy i s the preferred procedure during the initial evaluation of upper gastrointe stinal bleeding. With its excellent success rates, many patients are being cured with endoscopic therapy followed by eradication of Helicobacter pylor i. H. pylori is now thought to have an important role in the pathogenesis o f a majority of gastric and duodenal ulcers. This finding has led to the re commendation that patients with peptic ulcer disease be treated with regime ns effective against this organism. Currently, patients who are older and w ho have more severe underlying medical conditions present a challenge. This review will address the options for treatment of peptic ulcer bleeding. In addition, knowledge gained regarding H. pylori infection and use of nonste roidal anti-inflammatory drugs will be discussed.