New approaches to treatment of patients with idiopathic mitral prolapse

Aim. To assess efficiency of magnerot, magnesium orotate, in patients with idiopathic mitral prolapse (IMP). Material and methods. 84 patients with IM P were randomized to the study group (43 patients) and control group (41 pa tients). Patients of the study group received magnerot tablets (Germany) co ntaining 500 mg of magnesium orotate (daily dose 3000 mg) for 6 months. The examination performed before the treatment and 6 months after it included: modified clinical and phenotypic records, echocardiography, 24-h ECG and A P monitoring, spectral analysis of cardiac rhythm variability, evaluation o f quality of life according to Visual Analog Scale and Disability Scale and of treatment results according to Clinical Global Impression scales, measu rements of magnesium in the hair by plasmic nuclear emission spectrometry, histological and histochemical skin tests. Results. IMP patients appeared to suffer from magnesium deficiency which is responsible for many symptoms in mitral prolapse. 6-month therapy with mag nerot completely or partially reduced the symptoms in more than half the pa tients. Positive changes were registered primarily in clinicofunctional man ifestations. Morphological changes in the skin correlating with the disease severity alleviated. Conclusion. Good objective and subjective response to magnerot 6-month ther apy (3000 mg/day) is demonstrated.