S. Cunha et al., Study of N-benzoyl-activation in the HgCl2-promoted guanylation reaction of thioureas. Synthesis and structural analysis of N-benzoyl-guanidines, TETRAHEDRON, 57(9), 2001, pp. 1671-1675
In this work, it is demonstrated that the benzoyl group is an activating gr
oup for thioureas in the HgCl2-guanylation reaction. Thus N-benzoyl-thioure
as containing electronically neutral and even electron-withdrawing or elect
ron-releasing substituents are converted into guanidines with reasonable yi
elds. In addition, NMR and X-ray structural analyses were performed to unde
rstand the intra- and intermolecular features of the synthesized guanidines
. (C) 2001 Elsevier Science Ltd. All rights reserved.