Improved synthesis of functionalized molecular platforms related to marinecyclopeptides

We report an improved synthesis of new molecular platforms, functionalized for studies in molecular recognition and combinatorial chemistry. Their str uctures are related to naturally occurring marine cyclopeptides such as the Dolostatins and Dendroamides that feature side chain functionality positio ned on the same face of a rigid platform. Incorporation of methyl substitut ed oxazole and thiazole rings into the platforms enhances the rigidity of s tructure and significantly improves the yields of the macrocyclization reac tion in the synthesis. (C) 2001 Elsevier Science Ltd. All rights reserved.