Synthesis of bone-targeted oestrogenic compounds for the inhibition of bone resorption

Authors
Page, PCB Moore, JPG Mansfield, I McKenzie, MJ Bowler, WB Gallagher, JA
Citation
Pcb. Page et al., Synthesis of bone-targeted oestrogenic compounds for the inhibition of bone resorption, TETRAHEDRON, 57(9), 2001, pp. 1837-1847
Citations number
60
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
57
Issue
9
Year of publication
2001
Pages
1837 - 1847
Database
ISI
SICI code
0040-4020(20010225)57:9<1837:SOBOCF>2.0.ZU;2-1
Abstract
Syntheses have been realised for several members of a new class of potentia l bone resorption inhibitors consisting of steroidal oestrogenic compounds linked at the 17 position to a geminal bia(phosphonic acid) moiety through an eater linkage. The approach used has the potential to allow other biolog ically active compounds to be coupled to the geminal bisphosphonate unit. ( C) 2001 Elsevier Science Ltd. All rights reserved.