Rh-catalyzed asymmetric hydrogenation by using a new family of C-2-symmetric bisphosphinites and a bisaminophosphine as ligands

Authors
Zhang, A Jiang, B
Citation
A. Zhang et B. Jiang, Rh-catalyzed asymmetric hydrogenation by using a new family of C-2-symmetric bisphosphinites and a bisaminophosphine as ligands, TETRAHEDR L, 42(9), 2001, pp. 1761-1763
Citations number
29
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
9
Year of publication
2001
Pages
1761 - 1763
Database
ISI
SICI code
0040-4039(20010226)42:9<1761:RAHBUA>2.0.ZU;2-M
Abstract
The application of a new family of four-chiral-centered C-2-symmetric bisph osphinites (1, 2 and 3) and the bisaminophosphine 4 in Rh-catalyzed asymmet ric hydrogenation of dehydroamino acids has been examined. Up to 98% ee was obtained in the hydrogenation of alpha -acetamidocinnamic acid, which is c omparable with the enantioselection obtained from the best chiral bisphosph inites and bisaminophosphines. (C) 2001 Elsevier Science Ltd. All rights re served.