Regioselective alkylation of guanines using 2-acetoxytetrahydrofurans

Authors
Geen, GR Kincey, PM Spoors, PG
Citation
Gr. Geen et al., Regioselective alkylation of guanines using 2-acetoxytetrahydrofurans, TETRAHEDR L, 42(9), 2001, pp. 1781-1784
Citations number
16
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
9
Year of publication
2001
Pages
1781 - 1784
Database
ISI
SICI code
0040-4039(20010226)42:9<1781:RAOGU2>2.0.ZU;2-I
Abstract
Reaction of silylated guanine derivatives with 2-acetoxy-4-benzoyloxymethyl tetrahydrofuran in DMF or NMP resulted in selective N-9 alkylation. This wa s used as the basis for a regioselective synthesis of the anti-viral agents famciclovir and penciclovir. (C) 2001 Elsevier Science Ltd. All rights res erved.