A review of mechanisms controlling ovulation with implications for the anovulatory effects of polychlorinated dibenzo-p-dioxins in rodents

Authors
Petroff, BK Roby, KF Gao, X Son, DS Williams, S Johnson, D Rozman, KK Terranova, PF
Citation
Bk. Petroff et al., A review of mechanisms controlling ovulation with implications for the anovulatory effects of polychlorinated dibenzo-p-dioxins in rodents, TOXICOLOGY, 158(3), 2001, pp. 91-107
Citations number
99
Categorie Soggetti
Pharmacology & Toxicology
Journal title
TOXICOLOGY
ISSN journal
0300483X → ACNP
Volume
158
Issue
3
Year of publication
2001
Pages
91 - 107
Database
ISI
SICI code
0300-483X(20010214)158:3<91:AROMCO>2.0.ZU;2-2
Abstract
Polychlorinated dibenzo-p-dioxins (PCDDs) can impinge on female fertility b y preventing ovulation. In this review, the aspects of normal ovulatory phy siology most relevant to our current understanding of PCDD action on the ov ary are briefly reviewed. This is followed by a comprehensive assessment of data relevant to the effects of PCDDs during ovulation in the rat. PCDDs i nterrupt ovulation through direct effects on the ovary in combination with dysfunction of the hypothalamo-hypophyseal axis. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.