The pharmacological treatment of erectile dysfunction has taken central imp
ortance among therapeutic approaches for this increasingly recognized, wide
spread disorder. In the past decade and a half, the specialty of erectile d
ysfunction management has witnessed an enormous growth in basic scientific
interest which has been translated impressively to the clinical arena. Disc
overies of regulatory mechanisms involved in penile erection have been garn
ered both at peripheral neurologic and end organ levels and at central brai
n and spinal cord levels. These discoveries along with ongoing investigatio
ns in the field provide a firm foundation for implementing exciting and eff
ective erectile dysfunction pharmacotherapies both now and in the future. T
he purpose of this report is to review the current trends and new direction
s in the pharmacotherapy of erectile dysfunction.